First steps towards modeling the interaction of cardiovascular agents and smooth muscle activation in arterial walls

Numerical simulation of the response healthy and pathological arteries to cardiovascular agents can provide valuable information physician in treatment diseases such as hypertension, atherosclerosis, Marfan syndrome. Here, we a first step towards computational framework model effects antihypertensive on mechanical arterial walls. A material is developed by extending an existing formulation for wall tissue incorporate calcium-ion channel blockers. The resulting coupled deformation-diffusion problem then solved using finite element method. Simulation results with drug activity show that, indeed, increased lumen diameter due reduced contraction obtained. Additionally, decrease rate observed, which also consistent expected behavior. Finally, compare implicit or explicit coupling, observe that both coupling schemes yield comparable wide range time sizes.